Bill Cosby paid nearly 3.4 million US dollars (£2.4 million) to the woman he is charged with sexually assaulting, a prosecutor has revealed to jurors.

District Attorney Kevin Steele highlighted the 2006 civil settlement during his opening statement in an apparent attempt to suggest Cosby would not have paid out so much money if the accusations against him were false.

Cosby’s lawyers have signalled they intend to seize on the settlement to argue that Andrea Constand falsely accused the former TV star in hopes of landing a big pay-off.

The amount had been confidential – and was kept out of the first trial – but a judge ruled that both sides could discuss it at this one.

“This case is about trust,” Mr Steele told the jury. “This case is about betrayal and that betrayal leading to the sexual assault of a woman named Andrea Constand.”

Cosby, 80, is charged with drugging and molesting Ms Constand, a former employee of Temple University’s basketball programme, at his suburban Philadelphia home in 2004.

Ms Constand says he gave her pills that made her woozy, then penetrated her with his fingers as she lay incapacitated, unable to tell him to stop.

“She’s unconscious. She’s out of it,” Mr Steele said.

“She will describe how her body felt during this circumstance. She’s jolted during this. She feels herself being violated. And she’ll tell you she remembers waking up on this sofa with her clothes dishevelled at 4 o’clock in the morning. This is hours after this starts.”

The defence was scheduled to make its opening statement later on Monday.

Cosby’s first trial last spring ended with the jury hopelessly deadlocked. The comedian faces three counts of aggravated indecent assault, each punishable by up to 10 years in prison.

Ahead of opening statements, a topless protester who appeared on several episodes of The Cosby Show as a child jumped a barricade and got within a few feet of Cosby as the comedian entered the courthouse.

The woman, whose body was scrawled with the names of more than 50 Cosby accusers as well as the words Women’s Lives Matter, ran in front of Cosby and toward a bank of TV cameras, but was intercepted by sheriff’s deputies and led away in handcuffs.

Bill Cosby arrives for his sexual assault trial at the Montgomery County Courthouse in Norristown (Corey Perrine/AP)
Bill Cosby arrives for his sexual assault trial at the Montgomery County Courthouse in Norristown (Corey Perrine/AP)

Cosby seemed startled by the commotion as a half-dozen protesters chanted at him.

The protester, Nicolle Rochelle, 39, of Little Falls, New Jersey, was charged with disorderly conduct and released.

“The main goal was to make Cosby uncomfortable because that is exactly what he has been doing for decades to women,” she said afterwards.

Opening statements were delayed for several hours while the judge sorted through allegations raised late on Friday that a juror told a woman during jury selection that he thought Cosby was guilty. Cosby’s lawyers wanted the juror removed from the case.

After questioning all 12 jurors and six alternates behind closed doors, Judge Steven O’Neill ruled the juror could stay, saying all of the jury members told him they stuck to their pledge to remain fair and impartial.

Prosecutors have lined up a parade of five additional accusers to make the case that the man revered as America’s Dad lived a double life as one of Hollywood’s biggest predators. Only one additional accuser took the stand at the first trial.

Cosby lawyer Tom Mesereau, who won an acquittal in Michael Jackson’s 2005 child molestation case, has said the jury will instead learn “just how greedy” Ms Constand was.

The Associated Press does not typically identify people who say they are victims of sexual assault unless they grant permission, which Constand has done.